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The Chemical Biology of Long Noncoding RNAs: Unlocking the Secrets of RNA Biology

Ian Powell

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Published in The Chemical Biology Of Long Noncoding RNAs (RNA Technologies 11)

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Long noncoding RNAs (lncRNAs) have emerged as a new frontier in molecular biology, revealing a previously uncharted world of gene regulation and cellular function. 'The Chemical Biology of Long Noncoding RNAs: RNA Technologies 11' provides a comprehensive overview of this rapidly evolving field, offering insights into the structure, function, and therapeutic potential of these enigmatic molecules.

The Chemical Biology of Long Noncoding RNAs (RNA Technologies 11)

The Chemical Biology of Long Noncoding RNAs (RNA Technologies Book 11)

5 out of 5

Language	:	English
File size	:	25516 KB
Text-to-Speech	:	Enabled
Screen Reader	:	Supported
Enhanced typesetting	:	Enabled
Print length	:	996 pages

Structure and Function of lncRNAs

LncRNAs are RNA molecules that are typically longer than 200 nucleotides but do not encode proteins. They exist in various forms, including linear, circular, and branched structures. Their functions are diverse and include:

Regulating gene expression by interacting with DNA, RNA, or proteins
Participating in chromatin remodeling and epigenetic modifications
Sponging miRNAs and modulating their regulatory effects
Controlling cellular processes such as cell growth, differentiation, and apoptosis

Techniques for Studying lncRNAs

The study of lncRNAs requires advanced techniques, including:

Next-generation sequencing (NGS): To identify and quantify lncRNAs in various biological samples
Chromatin immunoprecipitation sequencing (ChIP-seq): To determine the genomic binding sites of lncRNAs
RNA interference (RNAi): To knock down lncRNA expression and assess their functional roles
CRISPR-Cas systems: To edit lncRNA sequences and investigate their impact on gene regulation

Therapeutic Applications of lncRNAs

The discovery of lncRNAs' involvement in disease mechanisms has opened up new therapeutic avenues. LncRNAs have been implicated in a wide range of diseases, including:

Cancer
Neurodegenerative disFree Downloads
Cardiovascular diseases
Metabolic disFree Downloads

Targeting lncRNAs using various strategies, such as antisense oligonucleotides, CRISPR-Cas, and gene therapy, holds promise for developing novel treatments.

'The Chemical Biology of Long Noncoding RNAs: RNA Technologies 11' is an indispensable resource for scientists, researchers, and students interested in the emerging field of lncRNAs. It provides a comprehensive overview of the latest advances in lncRNA biology, from their structure and function to their therapeutic potential. By delving into the complexities of these enigmatic molecules, we can unlock new insights into gene regulation and pave the way for innovative treatments for various diseases.

The Chemical Biology of Long Noncoding RNAs (RNA Technologies Book 11)

5 out of 5